ACACB

Across TCGA pan-cancer cohorts, ACACB Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated ACACB data layer compared with 24 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ACACB Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ACACB expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, THYM, and SCLC are the cancer types where ACACB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.777	0.624	.016	30	view →
THYM	OS	Median	All	0.068	0.977	<.001	24	view →
SCLC	OS	Median	IV	0.137	0.548	.004	18	view →
OV	OS	Median	III,IV	0.556	0.838	.004	12	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	12	view →
LIHC	DFS	Median	III,IV	0.076	0.360	.001	12	view →
LUSC	OS	Median	III,IV	0.264	0.693	.011	9	view →
GBM	OS	Median	All	0.020	0.416	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LGG	OS	Median	All	0.604	0.889	.003	2	view →
BRCA	OS	Median	All	0.823	0.925	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

ACACB–UCEC (DFS)

Open the UCEC breakdown →