ACACB

Across TCGA pan-cancer cohorts, ACACB mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ACACB’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where ACACB mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ACACB is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

PDAC, HNSC, and LUAD are the cancer types where ACACB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACACB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−1.323	<.001	10	view →
HNSC	Male	II,III,IV	−1.018	<.001	8	view →
LUAD	All	All	−0.393	<.001	4	view →
CCRCC	Male	All	−0.164	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ACACB–PDAC

Open the PDAC breakdown →