ACAA2

Across TCGA pan-cancer cohorts, ACAA2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ACAA2 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ACAA2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACAA2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where ACAA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.487	0.926	.004	16	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	10	view →
CCRCC	DFS	Median	All	0.929	0.539	.004	8	view →
LUAD	DFS	Quartile	All	0.911	0.377	.003	7	view →
LSCC	DFS	Median	II,III,IV	0.843	0.988	.035	6	view →
PDAC	DFS	Tertile	All	0.838	0.740	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ACAA2–UCEC (DFS)

Open the UCEC breakdown →