ACAA2

Across TCGA pan-cancer cohorts, ACAA2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ACAA2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ACAA2 RNA is repressed in tumor relative to normal tissue. In most cancer types ACAA2 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and KIRP are the cancer types where ACAA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACAA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.990	<.001	12	view →
KICH	All	III,IV	−2.240	<.001	11	view →
KIRP	Male	III,IV	−1.336	<.001	10	view →
LUAD	Female	II,III,IV	−1.043	<.001	9	view →
LUSC	All	III,IV	−1.398	<.001	8	view →
LIHC	All	II,III,IV	−1.068	<.001	8	view →
BRCA	All	All	−1.044	<.001	6	view →
CHOL	Male	All	−2.258	<.001	5	view →
STAD	All	II,III,IV	+0.758	.006	4	view →
READ	All	All	−0.987	.001	3	view →
PRAD	All	All	−0.942	<.001	2	view →
UCEC	All	All	−0.691	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ACAA2–COAD

Open the COAD breakdown →