ACAA2

Across TCGA patient cohorts, ACAA2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACAA2-associated genes across cancer lineages are eIF4E, eIF4G, and JNK_pT183_Y185. Each is linked with ACAA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACAA2-to-partner and partner-to-ACAA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ACAA2-low versus ACAA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAA2→partner) and Y-score (partner→ACAA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.206	+3.013	.036	.018	3	1
UCEC	eIF4G →	+0.330	+2.584	.022	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.173	-3.169	.027	.019	3	1
UCEC	JNK2 →	+0.229	+2.834	.013	.034	3	1
UCEC	MEK1 →	+0.381	+3.321	.025	.010	3	1
UCEC	p62 Lck ligand →	+0.483	+2.584	.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eIF4E by ACAA2 expression — UCEC

Explore this box plot interactively →