ACAA1

Across TCGA pan-cancer cohorts, ACAA1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ACAA1 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ACAA1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ACAA1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where ACAA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.908	0.655	.003	24	view →
CCRCC	OS	Quartile	All	0.997	0.758	.005	23	view →
PDAC	DFS	Median	III,IV	0.343	0.970	.003	14	view →
GBM	OS	Quartile	All	0.441	0.726	.007	7	view →
LSCC	OS	Quartile	All	0.915	1.000	.042	2	view →
LUAD	DFS	Median	III,IV	0.508	0.973	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ACAA1–HNSC (DFS)

Open the HNSC breakdown →