ACAA1

Across TCGA patient cohorts, ACAA1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACAA1-associated genes across cancer lineages are EGFR_pY1068, Fibronectin, and FoxM1. Each is linked with ACAA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACAA1-to-partner and partner-to-ACAA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ACAA1-low versus ACAA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAA1→partner) and Y-score (partner→ACAA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.283	-2.321	.024	.035	3	1
UCEC	Fibronectin →	-0.351	-3.160	.034	.019	3	1
UCEC	FoxM1 →	+0.259	+2.321	.046	.035	3	1
UCEC	p70-S6K →	+0.225	+3.189	.020	.010	3	1
UCEC	STAT3_pY705 →	-0.393	-2.321	.002	.035	3	1
UCEC	TFRC →	+0.557	+2.321	.036	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by ACAA1 expression — UCEC

Explore this box plot interactively →