ACAA1

Across TCGA cell cohorts, ACAA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,350 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ACAA1-associated GO terms across cancer lineages are Toll-like receptor TLR6:TLR2 signaling pathway, Toll-like receptor 8 signaling pathway, and Lysosome organization. Each is linked with ACAA1 in more than 12 cancer types. Because this analysis shows association rather than direction, both ACAA1-to-partner and partner-to-ACAA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Toll-like receptor TLR6:TLR2 signaling pathway grouped by ACAA1-low versus ACAA1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAA1→partner) and Y-score (partner→ACAA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Toll-like receptor TLR6:TLR2 signaling pathway →	+0.214	+0.744	<.001	.001	3	13
CNS	Toll-like receptor 8 signaling pathway →	+0.889	+0.779	.001	<.001	3	13
BREAST	Lysosome organization →	+0.074	+1.260	<.001	<.001	3	11
BREAST	Lytic vacuole organization →	+0.074	+1.260	<.001	<.001	3	11
KIDNEY	Alpha-linolenic acid metabolic process →	+0.163	+0.727	<.001	.007	2	12
SOFT_TISSUE	GDP-mannose metabolic process →	+0.112	+0.622	.004	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,350 associations by consensus.

Toll-like receptor TLR6:TLR2 signaling pathway by ACAA1 expression — URINARY_TRACT

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