ABTB2

Across TCGA patient cohorts, ABTB2 mutation is significantly associated with the RNA expression of many other genes, with 693 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABTB2-associated genes across cancer lineages are PGA4, RPL31P13, and RNU4-35P. Each is linked with ABTB2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABTB2-to-partner and partner-to-ABTB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGA4 grouped by ABTB2-low versus ABTB2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABTB2→partner) and Y-score (partner→ABTB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PGA4 →	+0.016	+7.164	<.001	<.001	3	3
CESC	RPL31P13 →	+0.171	+7.164	<.001	<.001	3	2
BLCA	RNU4-35P →	+0.460	+4.605	<.001	.004	3	2
LUAD	ABHD17AP7 →	+0.034	+7.930	<.001	.008	3	2
UCEC	NDUFAF5 →	+0.282	+2.001	.007	.002	3	2
UCEC	SGTA →	+0.416	+2.828	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 693 associations by consensus.

PGA4 by ABTB2 expression — CESC

Explore this box plot interactively →