ABRA

Across TCGA patient cohorts, ABRA mutation is significantly associated with the RNA expression of many other genes, with 1,587 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABRA-associated genes across cancer lineages are RPL26P3, RNU6-1150P, and BNIP3P31. Each is linked with ABRA in more than 2 cancer types. Because this analysis shows association rather than direction, both ABRA-to-partner and partner-to-ABRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL26P3 grouped by ABRA-low versus ABRA-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABRA→partner) and Y-score (partner→ABRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RPL26P3 →	+0.093	+5.033	<.001	.009	3	3
LIHC	RNU6-1150P →	+0.338	+6.676	<.001	<.001	3	2
LIHC	BNIP3P31 →	+0.071	+5.033	.006	.009	3	2
HNSC	RNU6-542P →	+0.292	+4.912	<.001	.005	3	2
HNSC	MTDHP5 →	+0.076	+4.655	<.001	.007	3	2
UCEC	FAM219B →	+0.574	+2.818	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,587 associations by consensus.

RPL26P3 by ABRA expression — LIHC

Explore this box plot interactively →