ABRA

Across TCGA patient cohorts, ABRA mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABRA-associated genes across cancer lineages are eEF2, Notch1, and YAP_pS127. Each is linked with ABRA in more than 1 cancer types. Because this analysis shows association rather than direction, both ABRA-to-partner and partner-to-ABRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ABRA-low versus ABRA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABRA→partner) and Y-score (partner→ABRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eEF2 →	+0.369	+2.459	.019	.020	3	2
UCEC	Notch1 →	+0.172	+3.183	.002	.009	3	2
UCEC	YAP_pS127 →	+0.307	+1.906	.018	.016	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.509	-2.459	.002	.020	3	1
SKCM	PDK1_pS241 →	-0.183	-2.442	.020	.020	3	1
SKCM	Bap1-c-4 →	+0.297	+2.459	.041	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eEF2 by ABRA expression — SKCM

Explore this box plot interactively →