ABL2

Across TCGA cell cohorts, ABL2 mutation is significantly associated with the RNA expression of many other genes, with 193 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABL2-associated genes across cancer lineages are REG1B, RESP18, and GPR148. Each is linked with ABL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABL2-to-partner and partner-to-ABL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by ABL2-low versus ABL2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABL2→partner) and Y-score (partner→ABL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	1
BREAST	RESP18 →	+0.072	+5.169	<.001	.005	3	1
OVARY	GPR148 →	+0.047	+4.095	<.001	.003	3	1
OVARY	FCER1A →	+0.061	+3.791	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	ZNF716 →	+0.016	+5.357	<.001	.003	3	1
LUNG_NSCLC_LUAD	TSPAN16 →	+0.041	+2.894	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 193 associations by consensus.

REG1B by ABL2 expression — BREAST

Explore this box plot interactively →