ABI2

Across TCGA patient cohorts, ABI2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABI2-associated genes across cancer lineages are A-Raf_pS299, JNK2, and p62 Lck ligand. Each is linked with ABI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABI2-to-partner and partner-to-ABI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ABI2-low versus ABI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABI2→partner) and Y-score (partner→ABI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.102	-2.321	.011	.005	3	2
UCEC	JNK2 →	+0.249	+3.611	<.001	.001	3	2
UCEC	p62 Lck ligand →	+0.327	+1.331	.002	.043	3	2
UCEC	STAT3_pY705 →	-0.397	-2.201	<.001	<.001	3	2
UCEC	ATM →	-0.338	-2.115	.026	.017	3	2
UCEC	eIF4G →	+0.254	+2.321	.014	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

A-Raf_pS299 by ABI2 expression — UCEC

Explore this box plot interactively →