ABI2

Across TCGA pan-cancer cohorts, ABI2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ABI2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ABI2 RNA is repressed in tumor relative to normal tissue. In most cancer types ABI2 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, HNSC, and LIHC are the cancer types where ABI2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABI2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.727	<.001	10	view →
HNSC	Male	III,IV	+0.931	<.001	8	view →
LIHC	Female	II,III,IV	+0.848	<.001	7	view →
KIRC	Male	II,III,IV	−0.477	<.001	7	view →
LUAD	Female	III,IV	−0.896	<.001	6	view →
BLCA	Male	IV	−0.985	.003	5	view →
LUSC	All	All	−0.355	.002	5	view →
CHOL	Female	All	+2.183	<.001	3	view →
COAD	All	II,III,IV	+0.349	.012	3	view →
UCEC	All	All	−0.589	.004	2	view →
READ	All	III,IV	+0.459	.029	2	view →
PAAD	All	All	+0.382	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ABI2–KICH

Open the KICH breakdown →