ABI2

Across TCGA cell cohorts, ABI2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ABI2-associated genes across cancer lineages are PROP1, MSGN1, and FAM71C. Each is linked with ABI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABI2-to-partner and partner-to-ABI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by ABI2-low versus ABI2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABI2→partner) and Y-score (partner→ABI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PROP1 →	+0.023	+3.874	.001	.005	3	1
SKIN	MSGN1 →	+0.054	+4.437	<.001	.004	3	1
SKIN	FAM71C →	+0.015	+4.510	<.001	.001	3	1
SKIN	SLC4A1 →	+0.293	+3.938	<.001	.005	3	1
LARGE_INTESTINE	OR2AJ1 →	+0.015	+3.684	<.001	.006	3	1
LARGE_INTESTINE	C10orf53 →	+0.015	+4.217	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PROP1 by ABI2 expression — BLOOD_Leukemia

Explore this box plot interactively →