ABHD8

Across TCGA patient cohorts, ABHD8 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABHD8-associated genes across cancer lineages are FOXO3a, Ku80, and p62 Lck ligand. Each is linked with ABHD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABHD8-to-partner and partner-to-ABHD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by ABHD8-low versus ABHD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABHD8→partner) and Y-score (partner→ABHD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	+0.152	+3.013	.009	.019	3	2
UCEC	Ku80 →	+0.388	+3.013	.004	.019	3	1
UCEC	p62 Lck ligand →	+0.530	+3.009	.004	.019	2	1
UCEC	eIF4G →	+0.396	+3.000	.027	.037	1	1
UCEC	p70-S6K →	+0.276	+3.026	.013	.019	1	1
UCEC	PKC-a_pS657 →	-0.441	-2.986	.045	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FOXO3a by ABHD8 expression — UCEC

Explore this box plot interactively →