ABHD8

Across TCGA cell cohorts, ABHD8 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ABHD8-associated genes across cancer lineages are TBC1D21, GP2, and REG1B. Each is linked with ABHD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABHD8-to-partner and partner-to-ABHD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by ABHD8-low versus ABHD8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABHD8→partner) and Y-score (partner→ABHD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GP2 →	+0.695	+3.556	<.001	.007	3	1
LARGE_INTESTINE	REG1B →	+2.007	+4.518	.002	<.001	3	1
LARGE_INTESTINE	FOXI2 →	+0.016	+3.632	<.001	.003	3	1
BLOOD_Leukemia	BTBD16 →	+0.095	+3.281	<.001	.003	3	1
BLOOD_Leukemia	HABP2 →	+0.380	+3.007	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

TBC1D21 by ABHD8 expression — LARGE_INTESTINE

Explore this box plot interactively →