ABHD4

Across TCGA pan-cancer cohorts, ABHD4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ABHD4 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ABHD4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ABHD4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where ABHD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.494	1.000	.016	32	view →
HNSC	OS	Median	All	1.000	0.959	.023	4	view →
CCRCC	DFS	Median	III,IV	1.000	0.821	.020	2	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.860	.035	2	view →
PDAC	OS	Tertile	All	0.369	0.724	.037	2	view →
LUAD	DFS	Median	All	0.500	0.726	.043	2	view →
GBM	OS	Median	All	0.857	0.853	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ABHD4–UCEC (OS)

Open the UCEC breakdown →