ABHD14B

Across TCGA pan-cancer cohorts, ABHD14B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ABHD14B data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ABHD14B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ABHD14B expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRP show a favorable association.

UVM, KIRP, and CESC are the cancer types where ABHD14B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.792	0.349	<.001	86	view →
KIRP	DFS	Tertile	All	0.713	0.496	<.001	74	view →
CESC	OS	Tertile	All	0.725	0.483	.004	60	view →
LGG	OS	Median	All	0.745	0.870	<.001	39	view →
READ	OS	Median	All	1.000	0.815	.005	39	view →
LIHC	OS	Tertile	II,III,IV	0.739	0.419	.002	39	view →
SKCM	DFS	Quartile	III,IV	0.432	0.823	.001	36	view →
LAML	DFS	Tertile	All	0.253	0.622	.001	36	view →
MESO	OS	Median	All	0.462	0.308	.017	18	view →
ACC	OS	Tertile	II,III,IV	0.935	0.637	.019	17	view →
HNSC	DFS	Median	IV	0.385	0.255	.017	17	view →
KIRC	DFS	Quartile	All	0.702	0.526	.017	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ABHD14B–UVM (DFS)

Open the UVM breakdown →