ABHD14B

Across TCGA pan-cancer cohorts, ABHD14B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ABHD14B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ABHD14B RNA is repressed in tumor relative to normal tissue. In most cancer types ABHD14B is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and LUSC are the cancer types where ABHD14B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABHD14B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.685	<.001	11	view →
HNSC	All	II,III,IV	−0.650	<.001	10	view →
LUSC	Male	All	−0.861	<.001	8	view →
KICH	Male	All	−1.020	<.001	7	view →
UCEC	All	II,III,IV	−1.291	<.001	6	view →
BRCA	All	All	−0.830	<.001	6	view →
LUAD	All	All	−0.374	<.001	5	view →
CHOL	All	All	−0.824	<.001	3	view →
STAD	Male	II,III,IV	+0.407	.040	1	view →
LIHC	Male	All	+0.341	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ABHD14B–KIRC

Open the KIRC breakdown →