ABHD14B

Across TCGA pan-cancer cohorts, ABHD14B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ABHD14B data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ABHD14B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ABHD14B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where ABHD14B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.827	0.311	<.001	71	view →
PDAC	OS	Tertile	All	0.568	0.276	<.001	66	view →
HNSC	DFS	Quartile	II,III,IV	0.457	0.835	<.001	26	view →
GBM	OS	Tertile	All	0.299	0.658	<.001	19	view →
LUAD	DFS	Median	III,IV	0.501	0.975	.001	13	view →
LSCC	DFS	Quartile	III,IV	0.493	1.000	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ABHD14B–CCRCC (DFS)

Open the CCRCC breakdown →