ABHD12

Across TCGA patient cohorts, ABHD12 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABHD12-associated genes across cancer lineages are IGFBP2, MSH2, and STAT3_pY705. Each is linked with ABHD12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABHD12-to-partner and partner-to-ABHD12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by ABHD12-low versus ABHD12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABHD12→partner) and Y-score (partner→ABHD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.864	-2.321	.003	.034	3	1
UCEC	MSH2 →	-0.231	-2.973	.026	.035	3	1
UCEC	STAT3_pY705 →	-0.273	-2.311	.020	.034	3	1
UCEC	TFRC →	+0.489	+2.000	.041	.032	3	1
UCEC	VHL →	-1.342	-3.459	<.001	.005	3	1
UCEC	Chk1 →	-0.166	-3.169	.026	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

IGFBP2 by ABHD12 expression — UCEC

Explore this box plot interactively →