ABHD12

Across TCGA pan-cancer cohorts, ABHD12 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ABHD12 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ABHD12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ABHD12 expression acts as an unfavorable survival marker, although some lineages such as SCLC and DLBC show a favorable association.

BRCA, LIHC, and KICH are the cancer types where ABHD12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	All	0.938	0.977	.002	86	view →
LIHC	OS	Quartile	All	0.549	0.796	<.001	53	view →
KICH	DFS	Tertile	II,III,IV	0.437	1.000	.004	52	view →
UVM	DFS	Tertile	All	0.352	0.809	.001	47	view →
MESO	OS	Tertile	All	0.249	0.495	<.001	31	view →
SCLC	OS	Median	All	0.788	0.495	.001	23	view →
KIRP	DFS	Tertile	All	0.814	1.000	.004	18	view →
SARC	DFS	Median	All	0.537	0.679	.002	12	view →
GBM	DFS	Median	All	0.159	0.245	.021	11	view →
DLBC	DFS	Median	All	0.912	0.636	.015	9	view →
SKCM	DFS	Quartile	II,III,IV	0.616	0.470	.014	7	view →
ACC	DFS	Tertile	IV	0.080	0.633	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ABHD12–BRCA (OS)

Open the BRCA breakdown →