ABCG5

Across TCGA patient cohorts, ABCG5 mutation is significantly associated with the RNA expression of many other genes, with 3,562 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCG5-associated genes across cancer lineages are CYCSP49, RN7SL654P, and RNA5SP412. Each is linked with ABCG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCG5-to-partner and partner-to-ABCG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP49 grouped by ABCG5-low versus ABCG5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG5→partner) and Y-score (partner→ABCG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CYCSP49 →	+0.160	+5.142	<.001	.002	3	2
SKCM	RN7SL654P →	+0.051	+4.640	<.001	.003	3	2
UCEC	RNA5SP412 →	+0.405	+1.613	<.001	.005	3	2
UCEC	LINC00869 →	-0.586	-3.137	<.001	<.001	3	2
UCEC	ADAM33 →	-0.841	-3.947	<.001	<.001	3	2
UCEC	MTA2 →	+0.452	+1.900	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,562 associations by consensus.

CYCSP49 by ABCG5 expression — COAD

Explore this box plot interactively →