ABCG4

Across TCGA patient cohorts, ABCG4 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCG4-associated genes across cancer lineages are Annexin-1, eIF4E, and Akt. Each is linked with ABCG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCG4-to-partner and partner-to-ABCG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by ABCG4-low versus ABCG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG4→partner) and Y-score (partner→ABCG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.633	+2.135	<.001	.010	3	3
UCEC	eIF4E →	+0.171	+2.906	.024	.001	3	2
UCEC	Akt →	-0.163	-2.212	.048	.010	3	2
UCEC	p62 Lck ligand →	+0.313	+1.925	.007	.005	3	2
COAD	PCNA →	+0.351	+2.820	.004	.035	3	2
UCEC	Rad50 →	-0.213	-1.584	.014	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Annexin-1 by ABCG4 expression — UCEC

Explore this box plot interactively →