ABCG4

Across TCGA pan-cancer cohorts, ABCG4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ABCG4 data layer compared with 5 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ABCG4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ABCG4 expression acts as an unfavorable survival marker, although some lineages such as THYM and THCA show a favorable association.

UVM, MESO, and BLCA are the cancer types where ABCG4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.417	0.705	<.001	97	view →
MESO	OS	Quartile	All	0.334	0.655	<.001	90	view →
BLCA	DFS	Tertile	All	0.411	0.614	<.001	86	view →
STAD	DFS	Quartile	II,III,IV	0.393	0.603	.006	67	view →
CESC	DFS	Tertile	All	0.743	0.902	.001	38	view →
BRCA	OS	Tertile	II,III,IV	0.877	0.936	.004	32	view →
THYM	OS	Median	All	1.000	0.629	<.001	27	view →
ACC	DFS	Quartile	III,IV	0.148	0.607	.006	25	view →
SKCM	OS	Quartile	All	0.707	0.844	.001	23	view →
THCA	OS	Tertile	III,IV	0.981	0.751	.012	21	view →
LUSC	OS	Median	III,IV	0.390	0.647	.014	21	view →
LUAD	OS	Tertile	II,III,IV	0.857	0.623	.002	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ABCG4–UVM (DFS)

Open the UVM breakdown →