ABCG4

Across TCGA cell cohorts, ABCG4 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCG4-associated genes across cancer lineages are DAZ2, EPX, and CPO. Each is linked with ABCG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCG4-to-partner and partner-to-ABCG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAZ2 grouped by ABCG4-low versus ABCG4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG4→partner) and Y-score (partner→ABCG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DAZ2 →	+0.117	+5.228	<.001	.005	3	2
LARGE_INTESTINE	EPX →	+0.076	+3.520	<.001	.005	3	1
LARGE_INTESTINE	CPO →	+0.112	+3.514	.003	.007	3	1
LARGE_INTESTINE	SAXO1 →	+0.056	+3.556	<.001	.007	3	1
LARGE_INTESTINE	CX3CR1 →	+0.230	+3.252	<.001	.009	3	1
LARGE_INTESTINE	SCN11A →	+0.112	+3.772	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

DAZ2 by ABCG4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →