ABCG1

Across TCGA pan-cancer cohorts, ABCG1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ABCG1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ABCG1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ABCG1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where ABCG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.969	0.776	.003	38	view →
LUAD	DFS	Quartile	All	0.820	0.989	.006	18	view →
HNSC	DFS	Median	III,IV	1.000	0.922	.010	17	view →
LSCC	DFS	Tertile	III,IV	0.896	0.343	.007	14	view →
PDAC	DFS	Median	III,IV	0.510	0.224	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ABCG1–CCRCC (DFS)

Open the CCRCC breakdown →