ABCG1

Across TCGA pan-cancer cohorts, ABCG1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ABCG1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ABCG1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ABCG1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, HNSC, and LUAD are the cancer types where ABCG1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCG1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.510	<.001	12	view →
HNSC	Female	II,III,IV	+1.452	<.001	12	view →
LUAD	Female	III,IV	−1.636	<.001	9	view →
KICH	Female	All	+1.543	<.001	7	view →
KIRP	Male	All	+1.024	<.001	7	view →
LIHC	Female	II,III,IV	+1.485	<.001	6	view →
LUSC	Female	All	−1.029	<.001	6	view →
BRCA	All	III,IV	+0.785	<.001	6	view →
STAD	All	II,III,IV	+0.757	.008	6	view →
THCA	All	All	+0.492	<.001	6	view →
CHOL	All	All	+1.674	<.001	5	view →
COAD	Female	II,III,IV	−0.740	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ABCG1–KIRC

Open the KIRC breakdown →