ABCG1

Across TCGA patient cohorts, ABCG1 mutation is significantly associated with the RNA expression of many other genes, with 3,277 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCG1-associated genes across cancer lineages are CDK2, OR1M4P, and XYLB. Each is linked with ABCG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCG1-to-partner and partner-to-ABCG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK2 grouped by ABCG1-low versus ABCG1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG1→partner) and Y-score (partner→ABCG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDK2 →	+1.214	+3.826	<.001	<.001	3	3
COAD	OR1M4P →	+0.116	+4.824	.009	.002	3	3
SKCM	XYLB →	+0.668	+2.597	.001	.005	3	3
UCEC	FANCA →	+0.611	+2.192	<.001	<.001	3	3
UCEC	RNA5SP451 →	+0.152	+2.086	.001	.006	3	3
UCEC	FAM177A1 →	+0.312	+2.534	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,277 associations by consensus.

CDK2 by ABCG1 expression — SKCM

Explore this box plot interactively →