ABCG1

Across TCGA patient cohorts, ABCG1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCG1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, CDK1, and 4E-BP1_pT70. Each is linked with ABCG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCG1-to-partner and partner-to-ABCG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by ABCG1-low versus ABCG1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG1→partner) and Y-score (partner→ABCG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p38-MAPK_pT180_Y182 →	-0.294	-1.807	.039	.026	3	3
SKCM	CDK1 →	+0.189	+2.459	.007	.018	3	3
SKCM	4E-BP1_pT70 →	+0.158	+1.824	.033	.015	3	3
UCEC	JNK_pT183_Y185 →	-0.127	-1.440	.014	.022	3	2
UCEC	ATM →	-0.469	-2.074	<.001	.004	3	2
UCEC	Caspase-8 →	-0.283	-1.947	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

p38-MAPK_pT180_Y182 by ABCG1 expression — SKCM

Explore this box plot interactively →