ABCG1

Across TCGA cell cohorts, ABCG1 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ABCG1-associated genes across cancer lineages are OR52E2, OR10Q1, and ADORA3. Each is linked with ABCG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCG1-to-partner and partner-to-ABCG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52E2 grouped by ABCG1-low versus ABCG1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG1→partner) and Y-score (partner→ABCG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR52E2 →	+0.083	+4.927	.004	.001	3	2
LARGE_INTESTINE	OR10Q1 →	+0.073	+2.657	.008	.007	3	1
LARGE_INTESTINE	ADORA3 →	+0.037	+3.506	.005	.005	3	1
BLOOD_Lymphoma	DEFA1 →	+1.308	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	OR6B1 →	+0.009	+4.643	<.001	.005	3	1
CNS	ASGR2 →	+0.141	+4.034	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

OR52E2 by ABCG1 expression — BLOOD_Lymphoma

Explore this box plot interactively →