ABCD3

Across TCGA patient cohorts, ABCD3 mutation is significantly associated with the RNA expression of many other genes, with 2,963 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCD3-associated genes across cancer lineages are SLC6A17-AS1, MIR6803, and FAM162B. Each is linked with ABCD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCD3-to-partner and partner-to-ABCD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC6A17-AS1 grouped by ABCD3-low versus ABCD3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCD3→partner) and Y-score (partner→ABCD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SLC6A17-AS1 →	+0.142	+5.093	<.001	.008	3	2
UCEC	MIR6803 →	+0.066	+3.571	<.001	.009	3	2
UCEC	FAM162B →	-0.461	-1.696	.004	.007	3	2
UCEC	CRELD2 →	+0.517	+2.839	<.001	.001	3	2
UCEC	TSPYL2 →	+0.352	+2.010	.008	.005	3	2
UCEC	MAK16 →	+0.396	+1.999	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,963 associations by consensus.

SLC6A17-AS1 by ABCD3 expression — LUSC

Explore this box plot interactively →