ABCD3

Across TCGA pan-cancer cohorts, ABCD3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ABCD3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ABCD3 RNA is repressed in tumor relative to normal tissue. In most cancer types ABCD3 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and COAD are the cancer types where ABCD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.884	<.001	11	view →
KIRC	Male	III,IV	−0.912	<.001	11	view →
COAD	All	IV	−1.431	<.001	10	view →
BLCA	All	III,IV	+0.759	<.001	9	view →
KIRP	Male	All	−0.699	<.001	8	view →
HNSC	Male	II,III,IV	−0.631	<.001	8	view →
LUSC	Female	All	−0.732	<.001	6	view →
BRCA	All	II,III,IV	+0.568	<.001	6	view →
READ	All	All	−0.957	<.001	5	view →
LUAD	Female	II,III,IV	−0.484	.002	3	view →
UCEC	All	III,IV	+0.855	.042	2	view →
PRAD	All	All	−0.313	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ABCD3–KICH

Open the KICH breakdown →