ABCD3

Across TCGA patient cohorts, ABCD3 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCD3-associated genes across cancer lineages are p62 Lck ligand, VHL, and ATM. Each is linked with ABCD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCD3-to-partner and partner-to-ABCD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ABCD3-low versus ABCD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCD3→partner) and Y-score (partner→ABCD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.280	+3.469	.011	.002	3	2
UCEC	VHL →	-0.841	-2.502	<.001	.001	3	2
UCEC	ATM →	-0.515	-1.807	<.001	.025	3	2
UCEC	Di-Ras3 →	-0.143	-3.446	.004	.005	3	2
UCEC	eEF2 →	+0.262	+2.115	.031	.016	3	1
UCEC	EGFR_pY1068 →	-0.342	-2.999	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

p62 Lck ligand by ABCD3 expression — UCEC

Explore this box plot interactively →