ABCD2

Across TCGA cell cohorts, ABCD2 mutation is significantly associated with the RNA expression of many other genes, with 395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCD2-associated genes across cancer lineages are WFDC10A, IQCF5, and PDHA2. Each is linked with ABCD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCD2-to-partner and partner-to-ABCD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC10A grouped by ABCD2-low versus ABCD2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCD2→partner) and Y-score (partner→ABCD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	WFDC10A →	+0.048	+4.870	.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.042	+4.357	<.001	.006	3	1
LUNG_SCLC	PDHA2 →	+0.033	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	HAO1 →	+0.211	+3.132	<.001	.009	3	1
LUNG_NSCLC_LUAD	TAS2R9 →	+0.039	+3.695	.003	.005	3	1
LUNG_NSCLC_LUAD	KRTAP19-4 →	+0.141	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 395 associations by consensus.

WFDC10A by ABCD2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →