ABCD1

Across TCGA patient cohorts, ABCD1 mutation is significantly associated with the RNA expression of many other genes, with 2,125 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCD1-associated genes across cancer lineages are SKA1, CCNF, and ME2. Each is linked with ABCD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCD1-to-partner and partner-to-ABCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by ABCD1-low versus ABCD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCD1→partner) and Y-score (partner→ABCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SKA1 →	+0.910	+3.598	<.001	.001	3	3
UCEC	CCNF →	+0.550	+1.765	<.001	<.001	3	3
COAD	ME2 →	+0.953	+3.611	<.001	.001	3	3
COAD	CDCA2 →	+0.920	+3.598	<.001	.001	3	3
HNSC	BANF1P5 →	+0.171	+4.780	.007	.003	3	3
UCEC	STT3A →	+0.364	+2.272	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,125 associations by consensus.

SKA1 by ABCD1 expression — COAD

Explore this box plot interactively →