ABCD1

Across TCGA patient cohorts, ABCD1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCD1-associated genes across cancer lineages are Shc_pY317, ATM, and Caspase-7-cleavedD198. Each is linked with ABCD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCD1-to-partner and partner-to-ABCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by ABCD1-low versus ABCD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCD1→partner) and Y-score (partner→ABCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.112	-1.415	.027	.043	3	3
COAD	ATM →	-0.786	-3.169	<.001	.017	3	2
COAD	Caspase-7-cleavedD198 →	+1.614	+3.186	<.001	.009	3	2
UCEC	Notch1 →	+0.110	+1.321	.019	.029	3	2
UCEC	Cyclin-B1 →	+0.709	+2.584	<.001	<.001	3	2
UCEC	Di-Ras3 →	-0.121	-1.584	.014	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Shc_pY317 by ABCD1 expression — UCEC

Explore this box plot interactively →