ABCC8

Across TCGA patient cohorts, ABCC8 mutation is significantly associated with the RNA expression of many other genes, with 8,574 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC8-associated genes across cancer lineages are MIR4768, EMID1, and TYW3. Each is linked with ABCC8 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCC8-to-partner and partner-to-ABCC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4768 grouped by ABCC8-low versus ABCC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC8→partner) and Y-score (partner→ABCC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4768 →	-0.714	-1.467	.001	<.001	3	5
UCEC	EMID1 →	-1.030	-3.048	<.001	<.001	3	5
UCEC	TYW3 →	+0.442	+1.362	<.001	<.001	3	5
STAD	INTS13 →	+0.482	+3.016	.008	<.001	3	5
UCEC	SEH1L →	+0.330	+1.885	<.001	.001	3	5
STAD	PAICS →	+0.638	+3.496	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,574 associations by consensus.

MIR4768 by ABCC8 expression — UCEC

Explore this box plot interactively →