ABCC6P1

Across TCGA patient cohorts, ABCC6P1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC6P1-associated genes across cancer lineages are PRDX1, mTOR_pS2448, and p62 Lck ligand. Each is linked with ABCC6P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCC6P1-to-partner and partner-to-ABCC6P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by ABCC6P1-low versus ABCC6P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC6P1→partner) and Y-score (partner→ABCC6P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.338	+3.000	.004	.037	3	1
UCEC	mTOR_pS2448 →	-0.221	-3.000	.010	.037	2	1
UCEC	p62 Lck ligand →	+0.565	+2.817	.002	.036	2	1
UCEC	Tuberin →	+0.404	+2.817	.009	.036	2	1
UCEC	ERK2 →	+0.290	+3.000	.009	.037	1	1
UCEC	PCNA →	+0.331	+3.000	.008	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PRDX1 by ABCC6P1 expression — UCEC

Explore this box plot interactively →