ABCC5

Across TCGA cell cohorts, ABCC5 mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCC5-associated genes across cancer lineages are PFN3, GPR101, and ANHX. Each is linked with ABCC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCC5-to-partner and partner-to-ABCC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFN3 grouped by ABCC5-low versus ABCC5-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC5→partner) and Y-score (partner→ABCC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PFN3 →	+0.057	+4.450	<.001	.004	3	2
URINARY_TRACT	GPR101 →	+0.020	+5.087	<.001	.004	3	1
OVARY	ANHX →	+0.180	+4.807	<.001	.003	3	1
OVARY	MBD3L2 →	+0.623	+4.029	<.001	.009	3	1
OVARY	OR8D2 →	+0.017	+4.807	<.001	.003	3	1
BLOOD_Leukemia	UNC93A →	+0.128	+4.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

PFN3 by ABCC5 expression — OVARY

Explore this box plot interactively →