ABCC12

Across TCGA pan-cancer cohorts, ABCC12 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated ABCC12 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ABCC12 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ABCC12 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

ACC, KIRP, and UCEC are the cancer types where ABCC12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
KIRP	DFS	Median	All	0.519	0.920	<.001	24	view →
UCEC	DFS	Median	All	0.947	0.824	.011	24	view →
OV	OS	Median	All	0.244	0.690	.036	18	view →
LUAD	OS	Median	III,IV	0.057	0.680	<.001	14	view →
BRCA	DFS	Median	All	0.140	1.000	.001	12	view →
ESCA	OS	Median	All	0.211	0.876	.028	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	DFS	Median	II,III,IV	0.431	0.239	.013	6	view →
SCLC	DFS	Median	All	1.000	0.587	.013	4	view →
SARC	DFS	Median	All	0.328	0.615	.042	3	view →
COAD	OS	Median	All	0.705	0.876	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

ABCC12–ACC (DFS)

Open the ACC breakdown →