ABCC11

Across TCGA patient cohorts, ABCC11 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC11-associated genes across cancer lineages are mTOR_pS2448, c-Kit, and ASNS. Each is linked with ABCC11 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCC11-to-partner and partner-to-ABCC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ABCC11-low versus ABCC11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC11→partner) and Y-score (partner→ABCC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.106	-1.723	.006	.005	3	4
COAD	c-Kit →	-0.730	-2.991	.019	.036	3	3
UCEC	ASNS →	+0.400	+1.754	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.281	+3.169	<.001	<.001	3	3
LUAD	4E-BP1_pS65 →	+0.213	+2.597	<.001	.005	3	2
UCEC	FoxM1 →	+0.142	+1.137	.036	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

mTOR_pS2448 by ABCC11 expression — UCEC

Explore this box plot interactively →