Across TCGA pan-cancer cohorts, ABCB8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ABCB8 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ABCB8 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ABCB8 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, PRAD, and BLCA are the cancer types where ABCB8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.931	0.610	.009	20	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BLCA	OS	Median	IV	0.164	0.603	.005	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ABCB8 tumor-vs-normal RNA expression · all ABCB8 data types