Across TCGA pan-cancer cohorts, ABCB8 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ABCB8’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where ABCB8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ABCB8 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
COAD, BLCA, and HNSC are the cancer types where ABCB8 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCB8 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.