Across TCGA pan-cancer cohorts, ABCB8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ABCB8 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ABCB8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ABCB8 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where ABCB8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	III,IV	0.836	0.538	.020	7	view →
CCRCC	DFS	Quartile	III,IV	0.140	0.830	.038	6	view →
GBM	DFS	Quartile	All	0.530	0.330	.030	3	view →
LUAD	DFS	Median	III,IV	0.668	0.340	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ABCB8 tumor-vs-normal RNA expression · all ABCB8 data types