ABCB8

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ABCB8 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCB8-associated genes across cancer lineages are mTOR_pS2448, PKC-b-II_pS660, and VHL. Each is linked with ABCB8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCB8-to-partner and partner-to-ABCB8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB8→partner) and Y-score (partner→ABCB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECmTOR_pS2448 →-0.117-1.794.015.02432
UCECPKC-b-II_pS660 →-0.218-2.087.015.00532
UCECVHL →-0.471-1.584.032.01732
UCECATM →-0.593-1.716<.001.00332
UCEC4E-BP1_pT37_T46 →-0.258-1.794.034.02432
UCECCyclin-D1 →+0.148+2.222.004.00932
Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration