ABCB4

Across TCGA cell cohorts, ABCB4 mutation is significantly associated with the RNA expression of many other genes, with 983 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCB4-associated genes across cancer lineages are OR1K1, IL2, and TDRD5. Each is linked with ABCB4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCB4-to-partner and partner-to-ABCB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1K1 grouped by ABCB4-low versus ABCB4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB4→partner) and Y-score (partner→ABCB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR1K1 →	+0.072	+2.956	<.001	.008	3	3
BLOOD_Leukemia	IL2 →	+0.636	+4.013	<.001	<.001	3	2
BLOOD_Leukemia	TDRD5 →	+0.618	+3.392	<.001	.005	3	2
BLOOD_Leukemia	VWC2L →	+0.015	+3.661	<.001	.001	3	2
BLOOD_Leukemia	ADIPOQ →	+0.016	+3.269	<.001	.007	3	2
BLOOD_Leukemia	C13orf42 →	+0.034	+3.007	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 983 associations by consensus.

OR1K1 by ABCB4 expression — CNS

Explore this box plot interactively →