ABCB11

Across TCGA patient cohorts, ABCB11 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCB11-associated genes across cancer lineages are eIF4E, PKC-a_pS657, and PKC-a. Each is linked with ABCB11 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCB11-to-partner and partner-to-ABCB11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ABCB11-low versus ABCB11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB11→partner) and Y-score (partner→ABCB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.201	+3.906	.003	<.001	3	4
COAD	PKC-a_pS657 →	-0.351	-3.000	.008	.035	3	4
COAD	PKC-a →	-0.356	-3.000	.003	.035	3	3
UCEC	p62 Lck ligand →	+0.294	+2.807	.006	.002	3	3
UCEC	Cyclin-B1 →	+0.592	+1.938	.001	.001	3	3
LUAD	Axl →	-0.166	-2.973	.017	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

eIF4E by ABCB11 expression — UCEC

Explore this box plot interactively →