ABCB11

Across TCGA pan-cancer cohorts, ABCB11 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ABCB11’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ABCB11 RNA is repressed in tumor relative to normal tissue. In most cancer types ABCB11 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, BRCA, and KIRC are the cancer types where ABCB11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCB11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.580	<.001	11	view →
BRCA	All	II,III,IV	−0.257	<.001	6	view →
KIRC	Male	All	+0.014	.010	6	view →
CHOL	Female	All	−3.933	<.001	5	view →
LIHC	Female	All	−1.690	.002	5	view →
READ	All	All	−0.718	<.001	5	view →
BLCA	All	All	+0.236	.031	4	view →
STAD	Male	All	+0.105	<.001	4	view →
LUAD	All	IV	−0.110	.016	2	view →
LUAD	All	All	+0.081	.003	2	view →
THCA	All	All	−0.059	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 10 lineages.

ABCB11–COAD

Open the COAD breakdown →